Jose Mourinho suffered an unwanted career first when his side went down 1-0 to Everton in their opening game of the Premier League campaign.
Dominic Calvert-Lewin headed past Hugo Lloris 10 minutes into the second half to consign Spurs to a defeat.
It is the first time in Mourinho's 20-year coaching career that the Portuguese has started the league season with a loss.
The 57-year-old had a record of 11 wins and seven draws in his sides' first league matches of the season before the Toffees got the better of them in the Tottenham Hotspur Stadium.