Toronto FC ends its eight-game road trip against the MLS Cup champion Portland Timbers, while the Montreal Impact host the Colorado Rapids in a surprisingly enticing matchup.
| Friday, April 29 | |||||
| 7:00 | New York Red Bulls | - | FC Dallas | UniMas | |
| Saturday, April 30 | |||||
| 4:00 | Montreal Impact | - | Colorado Rapids | RDS/MLS Live | |
| 4:00 | Philadelphia Union | - | San Jose Earthquakes | MLS Live | |
| 4:00 | New York City FC | - | Vancouver Whitecaps | TSN/MLS Live | |
| 4:00 | Seattle Sounders | - | Columbus Crew | MLS Live | |
| 5:00 | Chicago Fire | - | D. | ||