A showdown in the mountains pits Real Salt Lake against the Colorado Rapids, with both sides looking to continue their fine starts to the season.
| Friday, April 8 | |||||
| 7:00 | Philadelphia Union | - | Orlando City | UniMas | |
| Saturday, April 9 | |||||
| 4:00 | Montreal Impact | - | Columbus Crew | MLS Live | |
| 4:00 | New England Revolution | - | Toronto FC | TSN4/MLS Live | |
| 5:30 | D. | ||||