An unexpected clash of first-place teams headlines the Week 13 slate as the Colorado Rapids host the Philadelphia Union.
| Friday, May 27 | |||||
| 7:00 | Sporting Kansas City | - | D.C. United | UniMas | |
| Saturday, May 28 | |||||
| 6:00 | Vancouver Whitecaps | - | Houston Dynamo | RDS/MLS Live | |
| 7:00 | New York Red Bulls | - | Toronto FC | MLS Live | |
| 7:30 | Columbus Crew | - | Real Salt Lake | MLS Live | |
| 7:30 | New England Revolution | - | Seattle Sounders | MLS Live | |
| 8:00 | Montreal Impact | - | LA Galaxy | MLS Live | |
| 8:30 | Chicago Fire | - | Portland Timbers | MLS Live | |
| 9:00 | Colorado Rapids | - | Philadelphia Union | MLS Live | |
| 10:30 | San Jose Earthquakes | - | FC Dallas | MLS Live | |
| Sunday, May 29 | |||||
| 4:30 | New York City FC | - | Orlando City | ESPN/MLS Live | |
All times p.