The New York Red Bulls travel to Toronto with first place in the East on the line, while Vancouver and Seattle clash with their playoff hopes on the line.
We are rapidly approaching the final month of the regular season, and with six weeks to go everything is up for grabs, from top to bottom, in both conferences.
The playoff picture will clear up a fair amount after this weekend's matches, from Toronto FC and the New York Red Bulls squaring off for first place in the East, to Seattle taking on Vancouver in a match that will all but eliminate the loser from serious playoff contention.