Mamelodi Sundowns are set to battle with Stellenbosch FC in the Premier Soccer League (PSL) match at the Loftus Versfeld Stadium on Wednesday.
The Tshwane giants will return to domestic league action following their win over Petro de Luanda and draw with Wydad Casablanca in the Caf Champions League.
Pitso Mosimane's men got their PSL title defence campaign back on track by defeating AmaZulu FC 1-0 at home in their last league game and they will now face a struggling Stellenbosch side.
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Stellies are winless in their last four league matches after drawing 1-1 with Sundowns' Tshwane rivals, SuperSport United, away in their previous match in the competition.