Spain will look to maintain their bid to qualify automatically for the 2018 FIFA World Cup when they travel to Macedonia on Sunday.
La Roja are ahead of Italy on goal difference in Group G, but with the Azzurri likely to beat Liechtenstein handsomely in their fixture on Sunday, Spain will want to do the same against their opponents.
The clash between Spain and Italy in September is likely to decide which of the two teams finishes top of the group, but if the pair draw—as they did in their first meeting—goal difference could well be crucial.