Liverpool travel to Southampton with the intention of recording a first league double over their opponents since 2014-15.
It will be the ninth occasion that Jurgen Klopp will pit his wits against the Saints; a side he has only previously beaten twice.
Virgil van Dijk, meanwhile, returns to St Mary's for the first time since his £75 million switch to Liverpool.
The centre-back can expect a hostile reception, but he won't be alone in that regard given the Reds' penchant for purchasing from the south-coast club.
LIVERPOOL INJURIES
Joe Gomez sat out the 2-2 draw with Tottenham last Sunday due to a knee issue and hasn't trained since so will again be absent.