Mauro Icardi and Radja Nainggolan are not part of Inter's project for next season, says the club's chief executive Giuseppe Marotta.
Icardi was stripped of the club's captaincy last season and subsequently left out by then head coach Luciano Spalletti, although he returned to action before the end of the season.
Spalletti has been replaced by Antonio Conte and Icardi, who has been linked with clubs including Serie A champions Juventus, has indicated he wants to stay.
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Nainggolan, meanwhile, struggled to make an impact in an injury-affected first season with the Nerazzurri after he joined from Serie A rivals Roma.