Gareth Bale is set to return to the starting XI at Santiago Bernabeu while Cristiano Ronaldo will lead the forward line with Borja Mayoral left out of the matchday squad.
Real Madrid returns to the Champions League on Tuesday knowing the tournament is the club's only realistic chance of silverware, and despite the lead over Roma, Zinedine Zidane is unlikely to take any chances.
Los Blancos lead 2-0 from the first leg against the Serie A outfit thanks to goals from Cristiano Ronaldo and Jese, and the former is set to lead the line in a central role at Santiago Bernabeu.