Both nations finished second in their respective group and will each fancy their chances of reaching the quarter-finals
The first Euro 2020 last-16 match takes place on Saturday evening when Wales and Denmark do battle at the Johan Cruyff Arena in Amsterdam.
After losing their opening game of Euro 2020 to minnows Finland in a match which was overshadowed by star playmaker Christian Eriksen suffering a cardiac arrest on the pitch, Denmark have shown remarkable mental fortitude to get to this point.
The 4-1 victory over Russia just a few days ago was one of the finest performances by any country in this tournament and that should give them plenty of confidence against a Wales team who have faced 16 shots on target already - the third-most in Euro 2020.