Isco was booed after making an angry gesture during Real Madrid's shock defeat to CSKA Moscow in midweek, but Santiago Solari does not believe it was aimed at the fans.
The Spain international has played a bit-part role for Madrid since returning from acute appendicitis in October, with Solari yet to start the midfielder in a La Liga match.
The 26-year-old also received criticism for appearing to refuse the captain's armband, although Marcelo clarified he wanted it to be given to the Brazilian's replacement Dani Carvajal instead.