Pep Guardiola fears Manchester City could be without Rodri for up to a month after he sustained a hamstring injury during the 5-1 Champions League win over Atalanta.
Spain international Rodri, who became the Premier League champions' record signing when he joined from Atletico Madrid in July, was deployed at centre-back alongside Fernandinho for the second time in the space of a week on Tuesday.
Having helped Guardiola's side keep a clean sheet in the 2-0 win over Crystal Palace on Saturday, the City boss again went with the midfield duo in central defence, with John Stones left on the bench.