The supporter was unable to be revived following the match at Parc Olympique Lyonnais.
A Lyon fan died of a heart attack after Lyon ended Paris Saint-Germain's unbeaten streak in Ligue 1, the French club confirmed.
There were joyous scenes at Parc Olympique Lyonnais on Sunday as third-placed Lyon defeated PSG 2-1 to end the league leader's record 36-match unbeaten streak. However, the triumph was overshadowed by the death of a Lyon supporter, who went into cardiac arrest and could not be revived.
Lyon released a statement offering its condolences to the family, while the club is planning to honor him before hosting Guingamp on Sunday.