The most high profile match for South African football fans was Manchester United hosting Barcelona.
The Red Devils lost 1-0 on the night and hardly threatened the visitor's goal. Lionel Messi was relatively quiet but it was his moment of magic that created the opportunity for Luis Suarez.
The former Liverpool striker headed the ball toward the goal before it was turned in by United's Luke Shaw.
In the other quarter-final Cristiano Ronaldo opened the scoring at the end of the first half in Amsterdam, before Ajax equalised in the first minute of the second half.