Chelsea will face Swedish side Malmo in the last 32 of the Europa League, while Arsenal have been paired with Belarusian outfit BATE Borisov.
Scottish champions Celtic will take in a tricky test against La Liga heavyweights Valencia.
Other notable ties include Lazio locking horns with Sevilla and Galatasaray taking on Benfica.
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Inter will try to make their way past Rapid Wien, Napoli tackle FC Zurich and Sporting meet Villarreal.
Arsenal will be looking to make it one step further than they managed in 2017-18, when they fell at the semi-final stage to eventual winners Atletico Madrid.