After youngster Marcus Rashford inspired a comeback victory against FC Midtjylland on Thursday, Louis van Gaal's side has been handed a two-leg face-off with its rival.
Manchester United has been drawn against Liverpool in the Europa League's last 16.
After Thursday saw the Red Devils come from two goals down on aggregate to beat FC Midtjylland 5-1 on the night and 6-3 over two legs, Louis van Gaal's men have been rewarded with an all-Premier League affair against their old rivals as they pursue what could be an unlikely route into Champions League qualification.