Next Sunday's Clasico will have an unfamiliar feel to it, as Barcelona and Real Madrid face off without the two players who have defined an era in the last decade.
Madrid are struggling to adapt to life without Cristiano Ronaldo, who left for Juventus in the summer having led the Blancos attack in stunning style since 2009.
And now Barcelona will also have to soldier on in the absence of their talisman.
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Lionel Messi was forced off after just 26 minutes on Saturday when he fell heavily on his right arm during Barca's 4-2 victory over fellow Liga challengers Sevilla.