The Man City star went down after tangling with Mauro Icardi on the edge of his own area, and was immediately replaced by Alex Sandro
Danilo was forced off during Brazil's clash with Argentina after the Manchester City full-back suffered a suspected ankle injury.
Brazil coach Tite opted to pick Danilo ahead of Alex Sandro for Tuesday's Superclasico in Jeddah, as first-choice right-back Dani Alves continues his recovery from a serious knee injury.
But less than 10 minutes into the second half of the game, Danilo saw his evening come to a premature end.
Editors' Picks
Tracking back in order to stop a dangerous incursion from Argentina striker Mauro Icardi, the City man went over heavily on his ankle as he conceded a corner.