The Mexican side advanced to the knockout round with a 4-1 win over Olimpia.
Pumas UNAM has qualified for the Copa Libertadores round of 16, advancing from Group 7 with a 4-1 win over Olimpia on Wednesday.
Pumas were down 1-0 at halftime, but goals from Gerardo Alcoba, Matias Britos, Eduardo Herrera and Ismael Sosa won the game for the home side.
Elsewhere, River Plate has assumed control of Group 1 with a 6-0 thrashing of The Strongest. The Argentine outfit was third in the group before kickoff but has moved into the top spot courtesy of its thrashing of the Bolivian side.