Puebla and Cesar Vallejo were held to home draws in the Copa Libertadores by Racing Club and Sao Paulo, respectively.
Mexican side Puebla surrendered the lead on two occasions as it was held to a 2-2 draw at home to Racing Club on Wednesday.
The Clausura 2015 Copa MX winners took the lead inside the opening minutes thanks to Argentine forward Matias Alustiza. The lead was shortlived, however, with Gustavo Bou restoring parity just 10 minutes later.
Alustiza put Puebla back ahead via the penalty spot, but Ricardo Noir struck 16 minutes from time to silence the home support.