Atletico Nacional and Boca Juniors prevailed against Rosario Central and Nacional respectively to setup a final-four showdown.
Atletico Nacional overcame Rosario Central 3-1 in a heated finish on Thursday to book a spot in the semifinals of the Copa Libertadores.
Second-half substitute Orlando Berrio scored in the fifth minute of injury time to seal Nacional's spot in the final four as a 3-2 winner on aggregate.
The quarterfinal second leg fixture in Colombia ended with four red cards shown in stoppage time, three of those to Rosario players - Esteban Burgos, Damian Musto and Giovani Lo Celso.