Antonio Conte's side take on the Saints for a place in the final, where either Manchester United or Tottenham await
Chelsea will attempt to book their place in the FA Cup final when they face Southampton at Wembley on Sunday.
It is the second meeting between the sides in the space of a week and, after coming out 3-2 winners at St Mary's last Saturday, the Blues will be aiming for a similar result.
Antonio Conte's side overcame Norwich, Newcastle United, Hull and Leicester to reach this stage and they have been forced into extra time twice already, a fate they will be eager to avoid at Wembley.