Casemiro felt Real Madrid failed to turn up for the first half of their 3-0 loss at Sevilla but does not believe the result will have an impact upon Saturday's derby against Atletico Madrid.
Andre Silva bagged a brace inside 21 minutes and Wissam Ben Yedder added further punishment for Julen Lopetegui's men before the interval.
It meant a first La Liga defeat of the season for Madrid, who failed to capitalise upon Barcelona's shock 2-1 loss at Leganes earlier on Wednesday.
Atleti beat Huesca 3-0 on Tuesday and are lurking two points behind Madrid in third ahead of the weekend showdown at the Santiago Bernabeu.