Bayer Leverkusen crashed out of the Europa League at the last-16 stage as it failed to overturn a 2-0 deficit against Villarreal.
Villarreal was rewarded for a stellar defensive showing as a 0-0 draw against Bayer Leverkusen was enough for the Spanish side to progress to the Europa League quarterfinals.
Marcelino's side traveled to the BayArena for Thursday's second leg with a 2-0 lead thanks to Cedric Bakambu's double in the first contest at El Madrigal.
And a resolute Villarreal defense protected that advantage brilliantly to frustrate a Leverkusen side that failed to show a clinical edge in front of goal.