Atletico Madrid winger Gelson Martins is expected to miss El Derbi at the Santiago Bernabeu on Saturday due to injury after he trained separately from his team-mates during Friday's session due to a bruised knee.
Atleti's Jose Gimenez is also still an injury concern after being withdrawn from Tuesday's clash with Huesca, though Diego Simeone was optimistic about the defender's availability.
Atletico are third in La Liga, two points behind joint leaders Barcelona and Madrid and Saturday's clash an early-season test for two of the top clubs in the league.
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Real are also facing injury concerns, having confirmed Brazil international Marcelo has been diagnosed with a calf problem after being forced off late in their 3-0 defeat to Sevilla on Wednesday.