Diego Simeone's troops racked up their eighth win in the last 10 Primera Division games with a goal in each half, as there was no sign of a Champions League hangover.
Koke and Fernando Torres were Atletico Madrid's heroes and Angel Correa added his own goal as they eased to a 3-0 win over Granada, pulling momentarily level on points with Liga leader Barcelona.
Diego Simeone's side knocked the holder out of the Champions League this week and moved level on points with the Liga leader thanks to a comfortable win at the Vicente Calderon against a team without a victory since March 3.