Diego Simeone's side enjoyed a famous win in their last competitive match beating Liverpool at Anfield in the Champions League, but domestically they have struggled on the road.
Los Rojiblancos have won just three of their 13 away games this term and this weekend they travel to an Athletic side who are notoriously tough to beat at home.
Athletic Club vs Atletico Madrid Latest Odds
The Basques have lost just three of their last 27 home league games and bet365 price them at 11/4 (3.75) to win on Sunday.