Spain will be without Alvaro Morata, Andres Iniesta and Dani Carvajal for their upcoming World Cup qualifiers as the trio have all been forced to withdraw.
La Roja announced the players had been ruled out for the international break:
According to Goal's Sacha Pisani, Carvajal could be out indefinitely following a diagnosis of "a viral infection that is affecting his pericardium, the membrane enclosing the heart."
Meanwhile, Iniesta and Morata have both suffered injuries to their left hamstrings, the former during Barcelona's 3-0 victory over Las Palmas on Sunday and the latter in Chelsea's 1-0 defeat to Manchester City the day prior.