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San Diego Chargers vs. Indianapolis Colts Betting Odds, Analysis, NFL Pick

The San Diego Chargers don't garner much respect around the NFL betting community, and for fair reason considering they tumbled to a 4-12 record last year.

But playing the Rodney Dangerfield role can lead to friendlier point spreads, especially on the road, and the Chargers are taking advantage, going 7-0 ATS on their last seven road trips. San Diego hits the road again this week, visiting struggling Indianapolis on Sunday afternoon.

Point spread: The Colts opened as three-point favorites; the total was 50.5 early in the week, according to sportsbooks monitored by Odds Shark.