According to The Athletic’s Zak Keefer, a team source indicated that Indianapolis Colts wide receiver Parris Campbell is presumably out for the season—as it would take ‘a minor miracle’ for him to return on the field at this point:
The Colts at this point believe WR Parris Campbell is done for the year, and would need "a minor miracle" to return, per source. Campbell had an impressive Week 1 before suffering a MCL injury on the second offensive snap of the second game of the season.