Playing Aaron Rodgers is never an easy task; couple that with the Jets having one of the best defenses in the NFL and some playmakers on offense, and you have yourself a serious issue. Then add on the fact that you’re playing on the road in New York. What also doesn’t help is the Colts play the Bills the week before, so they might be banged up a bit after what will probably be a tough matchup.
2. Home vs Detroit Lions
You can go back and forth on who the better team is between the Bills and Lions, but what makes the Lions matchup tougher than the Bills’ is that it happens after the Colts play the Bills and Jets on back-to-back weeks.