This is the matchup that will define the course of the game. The Colts have struggled against Derrick Henry in the past, but the run defense has been amazing this season, and is fresh off a dominant outing against Clyde Edwards-Helaire. Grover Stewart has taken a massive step forward, while linebackers Bobby Okereke and E.J. Speed have been impeccable blowing up holes and taking down ball carriers. The Colts are also expecting All-Pro linebacker Shaquille Leonard back after missing the first 3 games of the season. The Titans’ offense has not been good this year, and it starts with Henry, who is averaging just 3.