With the amount of injuries and a bunch of positive COVID-19 cases, I wanted to wait a little bit more on this one to have more clarity about what the matchups would be for this game.
Danny Pinter vs. Jeffery Simmons
Danny Pinter will make his first career start against a tough Titans front that is not that great against the pass but they are still really good at getting into the backfield. Most likely, Vrabel will try to line up Simmons on the right side of the Colts offensive line, for him to have favourable matchups against a struggling Glowinski and a center making his debut as a starter in the NFL.