The Indianapolis Colts picked the wrong week to have numerous key injuries and a COVID-19 outbreak. Overcoming the absence of DeForest Buckner and Denico Autry on the defensive line, two of the most productive players on one of the best defenses in the NFL this season, will be incredibly challenging.
Starting linebacker Bobby Okereke has been strong next to Darius Leonard, with the range and speed to get sideline to sideline and the athleticism to muddy things up for quarterbacks in short zones. Anthony Walker Jr. will likely see more time, and that is rarely a bad thing, but if the Titans exploit his weakness in the passing game the defense may have a tough day.