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Insider: How the Colts are going to replace Marlon Mack

Indianapolis Colts running back Jonathan Williams had a career day with 147 total yards from scrimmage. The Colts defeated the Jaguars 33-13. Clark Wade, Clark.Wade@Indystar.com

INDIANAPOLIS — A Colts team that’s about to hit the middle of the stretch run has lost its most productive weapon for an unspecified amount of time.

Marlon Mack, who fractured his right hand against Jacksonville on Sunday, underwent surgery Monday, according to Indianapolis coach Frank Reich. No timetable for Mack's return has been given.

Without the services of Mack, who is fifth in the NFL in rushing with 862 yards, Indianapolis will use a combination of Jordan Wilkins and Jonathan Williams at running back, and Nyheim Hines will likely continue to see most of his action on third down and in passing situations, such as the two-minute drill.