The Buffalo Bills are 6-2 against the spread their last eight times out as underdogs, winning five of those contests outright. The Indianapolis Colts are 15-2 straight up and 12-3-2 ATS the last 17 times they've gone out as a favorite. So winning trends clash when the Bills and Colts, former longtime division rivals, renew acquaintances Sunday afternoon at Ralph Wilson Stadium.
Point spread: The Colts opened as 2.5-point favorites; the total was 48 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 23.