The Colts might be without two key players on offense come Sunday. Those players are starting running back Marlon Mack and starting left tackle Anthony Castonzo. Missing those two key pieces would affect the play calling dramatically.
Without Mack, the Colts lose a playmaker who can spread the field as a receiver out of the backfield or as a dynamic runner. Without him, the Colts will probably call fewer running plays because they don’t have an effective back behind him that can be relied on.
But then you add losing Castonzo into the equation.