On a week filled with supposedly lopsided games, we open up with one, as the Giants (+ 380) make the trip all the way to the other coast to visit the 49ers (- 500) in San Francisco. I already think Thursday Night Football games are bad for the players, but imagine on top of having just 3 days rest having to make the 6 and a half hour plane flight, just not ideal. That might also be taken into account as to why the Niners are 10.5-point favourites thus far. For updated lines visit DraftKings Sportsbook.
Giants at Niners Week 3 NFL 2023 TNF picks, predictions
