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From Peyton Manning rivalry to DeflateGate: Tom Brady's most famous moments against Colts

Note: On Saturday, ESPN reported Tom Brady intends to retire after 22 seasons in the NFL.

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Brady and the Colts have had plenty of famous moments over the years. Here are 5.

Tom Brady makes first NFL start for Patriots against Colts

Brady, a sixth-round pick out of Michigan in the 2000 NFL draft, got his first start in the NFL on Sept. 30, 2001, after an injury knocked out starter Drew Bledsoe. It came against the Colts in Foxborough, and though it was a 44-13 win for the Patriots, it was far from remarkable for Brady.