Mack has been very effective all season long running the ball. He had 109 yards and a touchdown before he broke his hand against the Jaguars. But that broken hand will sideline him for awhile. Two backups need to step up in his stead.
Those guys are Jordan Wilkins and Jonathan Williams. Williams got the first meaningful carries of his career on Sunday when Mack went out. He ended up running for 116 yards on 13 carries. If he has another day like that on Thursday, the Colts will easily win.
Wilkins is still a little questionable to play on Thursday.