The Colts have their first and only primetime game in week 10. They travel to Tennessee to face the Titans for a Thursday Night bout, which marks their 14th away game of their 18 total TNF appearances. They have never faced the Titans in a TNF matchup at home.
Whatever disadvantage having to travel on a short week causes, there is no way the Colts can argue they don’t know their opponent well. The Titans are the primary rival for the Colts in an AFC South that has seen the Jaguars sink back to their status as a bottom feeder as well as watching Bill O’Brien toss a grenade into the Texans organization before being fired.