The Indianapolis Colts (+2.5)
(2-2) hope to snap a current 5-game winning streak against their divisional rival Tennessee Titans (-2.5) (2-2) at home. Rookie quarterback Anthony Richardson certainly changes the complexion of this AFC South matchup, with his dynamic ability to both throw and run. Colts will fans will also be patiently waiting to see if star running back Jonathan Taylor makes his season debut, who would definitely add big play ability in the ground game—even if he’s on an initial pitch count.
If the Colts are serious about ultimately winning the division this year, this is one they ideally should win—especially at the friendly confines of Lucas Oil Stadium.