This has always been a great rivalry. Having Peyton Manning and Tom Brady go after it year after year made this much watch TV. But now things have changed. The Colts are on the downswing while New England is still on top. Vegas has taken notice of that.
As of right now, the Patriots are 10.5 point favorites. That is a huge spread in the NFL. This is likely the spread for a few different reasons. New England just destroyed undefeated Miami, and have the reigning MVP. The Colts just lost to a winless team at home.