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The Indianapolis Colts (2-2) (+2.5) travel to Duval to take on the winless Jacksonville Jaguars (0-4). While ordinarily, you’d have to feel pretty about the traveling team in this scenario, the Colts franchise has not won in Jacksonville since 2014, when Andrew Luck was their starting quarterback—and they have a number of injuries, particularly on the defensive line and potentially with key offensive players.