Last decade, the Indianapolis Colts versus the New England Patriots was perhaps the greatest rivalry in the NFL, mainly driven by the Peyton Manning versus Tom Brady quarterback matchup.
The Patriots knocked the Colts out of the playoffs twice early on in Manning's career, and his Colts later got revenge by defeating New England in an AFC Championship game. It became a matchup of the league's best team against the league's best player, as the Patriots had a streak of three Super Bowls in four years at one point while Manning had a streak of four MVP awards in seven years.