The Pacers appeared on their way to their first win of the season on Monday. T.J. Warren scored five straight points to give Indiana its first lead of the night, a 94-90 advantage with 1:42 remaining.
But the Pistons (2-2) got two contested buckets from Luke Kennard and Derrick Rose down the stretch to move back in front and held on for a 96-94 victory.
With the loss, Indiana fell to 0-3 on the season, with two of those losses coming to the Pistons, who also handed the Pacers a 119-110 defeat last Wednesday at Bankers Life Fieldhouse.