The Redbirds traveled to Nashville, Tenn., and were promptly flattened in the first half on Nov. 10. Belmont rolled up 62 points by halftime en route to a 100-89 victory.
ISU, which had four games at home and three in the Cayman Islands since then, tries to avoid an early knockout Wednesday. The Redbirds (6-3) take on Illinois-Chicago (3-5) at 6 p.m. at Credit Union 1 Arena.
ISU slipped past UIC, 71-70, last year at Redbird Arena. However, two of the Flames' top scorers, Tarkus Ferguson and Godwin Boahen, weren't involved in the outcome.