Illinois freshman running back Mike Epstein limped to the locker room after suffering an undisclosed leg injury.
"It's always tough but I feel like we're really deep at running back," quarterback Jeff George Jr. said. "I have all the confidence in all our backs that whoever's out there is going to make a play."
Epstein was productive against the Hawkeyes, averaging 11.9 yards on seven carries. He had a long gain of 58 yards.
"We'll kind of let you know on that a little bit later on," Illinois coach Lovie Smith said of Epstein's injury.
The Illini missed him on offense.