Hull striker Dieumerci Mbokani has been ruled out for six weeks with a hamstring injury.
The DR Congo international, on loan from Dynamo Kiev for the season, was replaced by Oumar Niasse in the second half of Saturday's 1-1 draw with Burnley.
Abel Hernandez returned ahead of schedule from a hamstring injury of his own later in that game, giving Marco Silva's attacking options a boost.
Mbokani's absence was announced as part of an injury update on the Tigers' website which also featured news of defender Harry Maguire.
The 23-year-old played on against the Clarets after suffering a knee injury in the first half and Silva hailed his spirit and commitment.